癫痫杂志

癫痫杂志

伴中央颞区棘波的儿童癫痫临床分析

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目的回顾性分析伴中央颞区棘波的儿童癫痫(Benign childhood epilepsy with centrotemporal spikes, BECTS)临床资料, 总结其临床特点与用药的关系, 为此病治疗提供临床依据。 方法将2011年1月-2012年12月在广西医科大学第一附属医院儿科门诊就诊的112例诊断为BECTS的患儿按是否规则的服用抗癫痫药物治疗分为治疗组与非治疗组, 对两组患儿发病年龄、单次发作持续时间、发作频率、发作形式以及脑电图进行回顾性分析。 结果治疗组共79例经规则抗癫痫药治疗后单次发作持续时间明显缩短、表现为全身强直-阵挛发作的例数明显减少(P均<0.05)。发作频率≥3次/3月的患儿, 抗癫痫药可有效的控制或减少其发作(P<0.05), 发作频率≤2次/3月的患儿, 其发作频率的减少与是否用抗癫痫药无关(P>0.05)。治疗组中64例≥1年无癫痫发作, 其中发病年龄<7岁的29例, 平均服用抗癫痫药13.76个月后发作控制; 发病年龄≥7岁的35例, 平均服用抗癫痫药6.36个月后发作控制。 结论①单次发作持续时间长、发作频率≥3次/3月的BECTS患儿早期应用抗癫痫药治疗可有效的控制或减少其发作。②发病年龄越小(<7岁), 控制癫痫发作需要应用抗癫痫药的时间越长。

ObjectiveUsing retrospective study to analyze the data of 112 patients with benign childhood epilepsy with centrotemporal spikes (BECTS) and investigate the clinical characteristics and provide some clinical experience in treatment. MethodsWe collected the medical records of 112 cases of BECTS children in the First Affiliated Hospital of Guangxi Medical University of children's clinics from January 2011 to December 2012. According to whether taking antiepileptic drugs (AEDs) treatment regularly, the 112 cases with BECTS was divided into the treated group and the non-treated group, then analyzed the clinical characteristics between the two groups retrospectively, including age of onset, single episode duration, frequency of seizure, pattern of seizure and EEG performances. ResultsThrough regular AEDs treatment, the duration of a single attack was shortened, generalized tonic-clonic seizure(GTCS) was decreased significantly in the treatment group (P < 0.05). For patients whose seizure frequency was≥3 times/3 months, AEDs could effectively control or reduce their seizure frequency (P < 0.05), while AEDs had no obvious effect on the seizure frequency of those whose seizure frequency was≤2 times/3 months (P > 0.05). In the treatment group, 29 cases whose age < 7 controlled their epilepsy attacks after taking AEDs for average of 13.76 months, while 35 cases whose age≥7 controlled their epilepsy attacks after taking AEDs for average of 6.36 months. Conclusion①BECTS patients with a long duration of a single attack and seizure frequency more than 3 times/3 months could be effectively controlled after receiving early AEDs treatment.②The younger age of onset (< 7 years old) required longer AEDs treatment to control seizures.

关键词: 儿童癫痫; 运动性; 抗癫痫药; 治疗应用

Key words: Childhood epilepsy; Rolandic; Antiepileptic drugs; Therapeutic use

引用本文: 陈殷, 韩蕴丽. 伴中央颞区棘波的儿童癫痫临床分析. 癫痫杂志, 2016, 1(2): 127-131. doi: 10.7507/2096-0247.20150019 复制

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