癫痫杂志

癫痫杂志

癫痫泛化对呼吸障碍严重程度的影响

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目的癫痫发作期和发作后期的呼吸功能障碍是癫痫猝死(Sudden unexpected death in epilepsy, SUDEP)的一个重要原因, 但癫痫引起呼吸抑制的网络机制尚不明确。积极寻找一种能稳定监测呼吸功能并可控的癫痫大鼠模型将有助于对这一机制的研究。 方法课题组前期利用实时颞叶癫痫Long-Evans大鼠模型证明了癫痫发作过程中及发作后的意识障碍与脑干觉醒系统功能受抑制相关, 此研究拟利用相同的大鼠模型, 结合鼻热敏传感器测定鼻腔温度变化的方法, 观察癫痫部分性发作和部分继发全面性发作过程中呼吸的变化。 结果癫痫发作过程中呼吸明显受到抑制, 呼吸频率明显减慢(P < 0.05;n=21), 且呼吸减慢的严重程度与癫痫泛化时长明显相关(Pearson R=-0.73; P < 0.001;n=30)。 结论癫痫泛化可加重癫痫所致呼吸障碍的严重程度。此动物模型对探索癫痫导致呼吸功能障碍甚至SUDEP的网络机制具有重要意义。

ObjectiveImpaired breathing during and following seizures is an important cause of sudden unexpected death in epilepsy (SUDEP), but the network mechanisms by which seizures impair breathing have not been thoroughly investigated. Progress would be greatly facilitated by a model in which breathing could be investigated during seizures in a controlled setting. MethodRecent work with an acute Long-Evans rat model of limbic seizures has demonstrated that depression of brainstem arousal systems may be critical for impaired consciousness during and after seizures. We now utilize the same rat model to investigate breathing during partial seizures with secondary generalization. ResultBreathing is markedly impaired during seizures(P < 0.05;n=21), and that the severity of breathing impairment is strongly correlated with the extent of seizure propagation (Pearson R=-0.73;P < 0.001;n=30). ConclusionSeizure propagation could increase the severity of breathing impairment caused by seizures. Based on these results, we suggest that this animal model would help us to improve understanding of pathways involved in impairment of breathing caused by seizures and this is an important initial step in addressing this significant cause of SUDEP in people living with epilepsy.

关键词: 癫痫猝死; 呼吸功能障碍; 癫痫泛化; 颞叶癫痫; 全身强直阵挛发作

Key words: Sudden unexpected death in epilepsy; Breathing impairment; Seizure propagation; Temporal lobe epilepsy; Generalized tonic-clonic seizures

引用本文: 詹琼, 冯莉, 岳宗伟, 解媛媛, 龙莉莉, 肖波. 癫痫泛化对呼吸障碍严重程度的影响. 癫痫杂志, 2016, 2(5): 383-386. doi: 10.7507/2096-0247.20160067 复制

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