癫痫杂志

癫痫杂志

神经元移行障碍发病机制研究进展

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胚胎发育时期因各种因素引起的神经元移行障碍,常导致大脑皮质发育畸形(Malformation of cortical development,MCD),也是引起患儿发育迟缓和癫痫的常见原因。快速发展的分子生物学、影像学和基因遗传学丰富了大脑皮质发育的相关知识,畸形的报道不仅在数量和种类上有所增长,同时相关研究已经确定了几个基因,可能破坏神经细胞增殖、移行以及晚期皮层组织形成的每一个重要阶段。不同的MCD在临床表现上也有很大的表型异质性,现就MCD的发生机制、易感基因进行阐述,为MCD后期研究提供参考依据。

关键词: 皮质发育不良; 基因; 信号通路; 癫痫

引用本文: 齐晖, 高丽, 李岩, 范宏业, 杨柳, 曹睿明, 殷小静, 李俊龙. 神经元移行障碍发病机制研究进展. 癫痫杂志, 2017, 3(5): 419-422. doi: 10.7507/2096-0247.20170066 复制

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