癫痫杂志

癫痫杂志

102 例西藏地区癫痫患者共患抑郁、焦虑和抑郁伴焦虑的分析

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目的 分析西藏自治区癫痫患者共患抑郁、焦虑及抑郁伴焦虑的患病率及临床特点,旨在提高该地区诊疗水平。 方法 对 2017 年 1 月–12 月来西藏自治区人民医院神经内科住院的 102 例癫痫患者按照《中国精神障碍分类与诊断标准》第 3 版(CCMD-3)抑郁症、焦虑症的诊断标准,采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD 24 项)和汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA 14 项)进行抑郁、焦虑测定,并同时对不同性别、年龄、病程、发作频率、发作类型的癫痫患者共患抑郁、焦虑及抑郁伴焦虑情况进行分析。应用单因素分析对可能造成该地区癫痫患者共患抑郁、焦虑及抑郁伴焦虑的因素进行筛选,再用 Logistic 回归分析其影响因素。 结果 102 例患者中有 35 例(34.31%)共患抑郁,10 例(9.80%)共患焦虑,54 例(52.94%)共患抑郁伴焦虑。单因素分析结果显示,共患焦虑在病程、发作频率上差异有统计学意义(P<0.05),共患抑郁伴焦虑在发作频率上差异有统计学意义(P<0.05)。多因素 Logistic 回归分析显示:病程≤2 年的患者共患焦虑的可能性是病程>2 年患者的 10.1% [OR=0.101,95%CI(0.012,0.915),P<0.05],而发作频率不是共患焦虑的危险因素(P>0.05);发作频率>2 次/月癫痫患者共患抑郁伴焦虑的可能性是发作频率≤2 次/月患者的 4.853 倍[OR=4.853 95%CI(2.024,11.634),P<0.05]。 结论 西藏自治区癫痫患者共患抑郁、焦虑及抑郁伴焦虑的患病率较高,在诊治中应加强认识,给予恰当的预防及治疗,提高诊治水平。

Objectives To analyze the prevalence and clinical features of depression, anxiety, depression and anxiety in Tibetan patients with epilepsy and to improve the diagnosis and treatment. Methods 102 patients with epilepsy, who had been admitted to the Department of Neurology of the People's Hospital of Tibet Autonomous Region from January 2017 to December 2017, were diagnosed according to the Chinese Standard Classification and Diagnostic Criteria for Mental Disorders (3rd Edition) (CCMD-3). The Hamilton depression scale (HAMD 24 items) and the Hamilton anxiety scale (HAMA 14 items) were used to measure depression and anxiety. Different genders, ages, durations, frequency of attacks, and seizures types were analyzed for depression, anxiety, depression and anxiety. Univariate analysis was used to screen the factors that may cause depression, anxiety, depression and anxiety in patients with epilepsy. Logistic regression was used to analyze the risk factors of depression, anxiety, depression and anxiety in patients with epilepsy. Results Among the 102 patients with epilepsy, 35 (34.31%) comorbid depression, 10 (9.80%) comorbid anxiety, and 54 (52.94%) comorbid depression and anxiety. Univariate analysis showed that there was a significantly statistical difference in the duration of the disease and the frequency of seizures in local patients with epilepsy (P<0.05). There was a statistically significant difference in the frequency of epileptic seizures and anxiety (P<0.05). Multivariate logistic regression analysis showed that the probability of anxiety in patients with a disease duration of ≤2 years was only 10.1% of those with a course >2 years [OR=0.101, 95%CI (0.012, 0.915), P<0.05]; and the frequency of seizures was not an risk factors for epileptic comorbid with anxiety (P>0.05). The rate of depression and anxiety in patients with seizure frequency >2 times per month was 4.853 times higher than that of patients with seizure frequency ≤2 times per month [OR=4.853, 95%CI (2.024, 11.634), P<0.05]. Conclusions Tibetan patients with epilepsy have a high prevalence of depression, anxiety, depression and anxiety. In the diagnosis and treatment, we should strengthen the understanding and provide the appropriate prevention and treatment to improve the diagnosis and treatment level.

关键词: 癫痫; 共患病; 抑郁; 焦虑; 抑郁伴焦虑

Key words: Epilepsy; Comorbidit; Depression; Anxiety; Depression and anxiety

引用本文: 赵梦娇, 赵玉华. 102 例西藏地区癫痫患者共患抑郁、焦虑和抑郁伴焦虑的分析. 癫痫杂志, 2018, 4(5): 400-405. doi: 10.7507/2096-0247.20180066 复制

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