癫痫杂志

癫痫杂志

颞叶癫痫海马组织中相关蛋白及通道的研究进展

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癫痫发生在全球约 1%~2% 的人群中,其特点是周期性和不可预测的重复性癫痫发作并伴有急性全身和神经损伤。其中大多数药物难治性癫痫病例为颞叶癫痫(TLE),是一种类型相当独特的癫痫综合症,其发病机制尚不明确,可能与基因表达模式、细胞凋亡、神经胶质细胞增生、神经传递和信号传导异常,以及受体功能紊乱等有关。目前人类颞叶脑组织和癫痫动物模型发现了一系列的蛋白以及其涉及的相应信号通路参与 TLE 的形成,文章翻阅和整理了大量国内外相关文献,对 TLE 海马组织中相关蛋白及通道进行汇总,期望对临床治疗难治性癫痫提供依据和指导。

关键词: 颞叶癫痫; 海马; 蛋白质组学

引用本文: 李柯麓, 任惠. 颞叶癫痫海马组织中相关蛋白及通道的研究进展. 癫痫杂志, 2018, 4(6): 509-512. doi: 10.7507/2096-0247.20180082 复制

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