癫痫杂志

癫痫杂志

癫痫与昼夜节律

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癫痫是常见的神经系统疾病,由不同病因引起脑部神经元高度同步化异常放电所致,其发病率高,临床表现复杂,具有不可预测性。昼夜节律是调节机体行为、生理、生物化学的 24 h 模式。随着对癫痫研究的不断深入,癫痫与昼夜节律的关系越来越受到关注。癫痫发作具有昼夜节律,同一类型的癫痫在不同时间、不同状态发作的频率不同。癫痫发作可能会影响昼夜节律,包括睡眠与睡眠觉醒周期、核心体温、心血管参数、内分泌系统等。同时,昼夜节律变化可能导致癫痫发生,二者相互作用形成恶性循环,严重影响癫痫患者的工作、生活和学习。内源性昼夜节律系统可能是癫痫发作的独立危险因素。各种癫痫发作类型可能具有不同的昼夜节律分布,并且这些节律分布特点可能提供癫痫诊断线索和依据。明确癫痫发作的昼夜节律,根据其发作节律进行干预及治疗,既可以减少药物不良反应,还能有效控制癫痫发作。文章就癫痫与昼夜节律的相互关系进行综述。

关键词: 癫痫; 昼夜节律; 机制; 诊断; 治疗

引用本文: 张亚男, 孙晴晴, 林卫红, 魏春会, 王传蕾, 王赞. 癫痫与昼夜节律. 癫痫杂志, 2019, 5(1): 34-37. doi: 10.7507/2096-0247.20190007 复制

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